Evaluate antibody humanness using peptide search in natural antibody repertoires (OASis) and germline sequence identity.
Evaluate humannessHumanize an antibody using deep learning on natural antibody repertoires (Sapiens) or CDR grafting.
Humanize antibodyPerform mutations on an antibody sequence while monitoring sequence properties in real time.
Mutate antibodyOur pre-print is available on BioRxiv.
BioPhi was released on GitHub under the MIT license.
If you use BioPhi, please cite:
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil & Danny A. Bitton (2022) BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning, mAbs, 14:1, DOI: https://doi.org/10.1080/19420862.2021.2020203
BioPhi is based on antibody repertoires from the Observed Antibody Space database.
Antibody numbering is performed using ANARCI and the AbNumber package.
BioPhi is an open-source platform, please feel free to submit a ticket to report any issues or to propose new features.
Developers are welcome to contribute directly to BioPhi code, learn more in our GitHub repository.
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